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By adding an experimental drug to a standard chemotherapy regimen, a subset of patients with metastatic pancreatic cancer had a significantly longer period before the cancer progressed as compared with those who received the standard treatment. A Phase 2 clinical trial was led by an investigator at Fred Hutchinson Cancer Research Center. The...

The U.S. Food & Drug Administration just approved a new drug to treat people with hepatocellular carcinoma, the most common form of liver cancer. The drug, regorafenib, is the first and only therapy approved by the FDA in over a decade to show significant improvement in patients with the disease after standard treatments have failed. The research...

How often are safety concerns raised about a drug after it’s been approved by the FDA? Nicholas Downing, MD, of the Department of Medicine at Brigham and Women’s Hospital, and colleagues have found that for drugs approved between 2001 and 2010, nearly 1 in 3 had a postmarket safety event. The team defines postmarket safety events as those that lead...