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 •  September 25

Researchers at Dartmouth College have developed a technique to produce synthetic steroids that could pave the way for a cascade of new drug discoveries. The process, published in the journal Nature Chemistry, facilitates access to rare, mirror-image isomers of naturally occurring steroid structures. The technique, based on a series of new chemical...

phys.org

 •  July 31

The field of medicine has come a long way from using heroine as a cough remedy or magnet therapy to improve blood flow. These outdated methods were put to bed decades ago. But there are plenty of ancient medicinal practices that have stood the test of time. In fact, many of the life-saving pharmaceuticals we rely on today are derived from plants...

phys.org

 •  July 7

The ability to consistently create desirable molecules and avoid undesirable ones could greatly accelerate pharmaceutical production. Many molecules come in two mirror-image configurations, often labeled left-handed and right-handed. Usually, only one of the two is biologically desired, but the issue is more complicated than that, said Dr. Uttam...

phys.org

 •  June 29

Sydney researcher Lidia Matesic has developed a technique to speed up the development of nuclear medicines allowing hospitals to not only make nuclear medicine in-house, but also tailor-made to the patient. In remote hospitals, this would also allow a larger variety of these pharmaceuticals to be used. "We have some nuclear medicines that work...

phys.org

 •  June 22

Over the past five years, an iterative stochastic elimination (ISE) algorithm developed in the laboratory of Prof. Amiram Goldblum, at the Hebrew University of Jerusalem's Institute for Drug Research, has been applied to the discovery of potential drugs. The Institute is part of the School of Pharmacy in the Faculty Of Medicine. First tested to...

phys.org

 •  June 2

HarkerBIO is a "shining star" in the growing biotech ecosystem taking shape on the Buffalo Niagara Medical Campus. The small structural biology company determines 3-D structures of proteins for drug and biotech companies. That may sound straightforward – even simple – but the process is something right out of Star Trek. HarkerBIO uses sophisticated...

phys.org

 •  April 10

This approach could help researchers in pharmaceutical companies to generate hypotheses for drug discovery. For instance, strongly correlated disease-side-effect pairs identified by the patented invention could be beneficial for drug discovery in many ways. One could use the side-effect information to repurpose existing treatments (e.g. drugs...

phys.org

 •  April 6

Importance of kinetics Many diseases can be treated by activating or blocking a particular receptor in the body with a drug. 'For decades the affinity of a drug was the main focus of drug discovery– the attraction between the molecule and the receptor,' says Nederpelt. 'Since the past ten years, some researchers prefer to look at the speed at which...

phys.org

 •  February 14

(Phys.org) —Researchers have created a prototype system that uses a mathematical model to predict - and a portable inkjet technology to produce - precise medication dosages tailored for specific patients, an advance in personalized medicine that could improve drug effectiveness and reduce adverse reactions. Drug makers now manufacture tablets based...

phys.org

 •  February 14

Tiny, inorganic quantum-dot crystals are finding increasing use as biological probes due to their powerful optical characteristics. By stimulating the dots with laser light, researchers can obtain sharp images to monitor processes such as drug delivery for much longer time frames than nearly any other technique. However, a key challenge lies in...